Chemopreventive effects of ferulic acid on oral and rice germ on large bowel carcinogenesis.


In wheat, phenolic compounds are mainly found in the form of insoluble bound ferulic acid and may be relevant to resistance to wheat fungal diseases. In this article, several methods for preparing ferulic acid will be introduced.

In the direct extract, the ferulic acid content is relatively low and further purification is required.

In wheat grain, ferulic acid is found bound to cell wall polysaccharides, allowing it to be released and absorbed in the small intestine.

Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells. Tomaro-Duchesneau C, Saha S, Malhotra M, Coussa-Charley M, Kahouli I, Jones ML, Labbé A, Prakash S. Pharmaceuticals (Basel). 2012 Feb 16;5(2):236-48. doi: 10.3390/ph5020236.

Commonly used solvents for extracting ferulic acid are mainly ethanol, ethyl acetate and the like.

Convenient, the yield is up to 85.7%, and the by-product is ringwood pineapple alcohol.

[12], Cooked sweetcorn releases increased levels of ferulic acid.

Ferulic acid is a hydroxycinnamic acid, an organic compound. In vitro results revealed that all the target compounds were highly effective and selective butyrylcholinesterase (BuChE) inhibitors.

The method is simple, but the yield is low and the energy consumption is large, which is the most commonly used method for purifying ferulic acid. The chemical synthesis method of ferulic acid is based on vanillin. [10], Ferulic acid has been identified in Chinese medicine herbs such as Angelica sinensis (female ginseng), Cimicifuga heracleifolia[11] and Ligusticum chuangxiong. 2011 Mar 9;59(5):1862-70. doi: 10.1021/jf1038103. Ferulic acid is found in a number of vegetable sources, and occurs in particularly high concentrations in popcorn and bamboo shoots. We suggest that chemical raw materials can best be obtained from natural resources. HHS

The tea brewed from the leaves of yacón (Smallanthus sonchifolius), a plant traditionally grown in the northern and central Andes, contains quantities of ferulic acid. Preparation of ferulic acid and its application for the synthesis of cancer chemopreventive agents. In plants, ferulic acid is cross-linked with polysaccharides and lignin by ester bonds or self-esterified or etherified to form diferulic acid.

[15] Rye bread contains ferulic acid dehydrodimers. Biosynthesis is the conversion of ferulic acid precursor to ferulic acid by several microorganisms (Arthrobacter Blobiformis), such as the conversion of eugenol cinnamate extracted from clove oil to ferulic acid.

It is also found in the tea brewed from the European centaury (Centaurium erythraea), a plant used as a medical herb in many parts of Europe.

A small amount of organic base is added as a catalyst in the pyridine solvent, and Kneoevenagel reacts with vanillin and malonic acid to form ferulic acid. Hudson EA, Dinh PA, Kokubun T, Simmonds MS, Gescher A. [5], In cereals, ferulic acid is localized in the bran – the hard outer layer of grain. 2012 Jul;13(8):1083-8. doi: 10.2174/138945012802009008. Triethyl phosphite acetate and acetyl vanillin undergo a Wittig-Horner reaction in a strong base system, and acidified with concentrated hydrochloric acid to obtain ferulic acid. After the extract is adsorbed by activated carbon, when the activated carbon reaches adsorption saturation, the pure ferric acid can be obtained from the extract by elution.

Epub 2011 Feb 9. Amended final report on the safety assessment of Oryza Sativa (rice) Bran Oil, Oryza Sativa (rice) Germ Oil, Rice Bran Acid,Oryza Sativa (rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (rice)Bran Extract, Oryza Sativa (rice) Extract, Oryza Sativa (rice) Germ Powder, Oryza Sativa (rice) Starch, Oryza Sativa (rice) Bran, Hydrolyzed Rice Bran Extract, Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein. There are currently not many methods for purifying ferulic acid. [7] It is also found in barley grain. A ferulic acid derivative, ethyl 3-(4'-geranyloxy-3-methoxyphenyl)-2-propenoate, as a new candidate chemopreventive agent for colon carcinogenesis in the rat.

Epub 2008 Sep 10.

Cancer Epidemiol Biomarkers Prev.

We suggest that chemical raw materials can best be obtained from natural resources. Ferulic acid has anti-oxidation and anti-radiation properties.

The structural unit containing ferulic acid in oryzanol exists in the form of ester and is easy to decompose. [9] It is also found in horse grams (Macrotyloma uniflorum).

[21], It can be extracted from wheat bran and maize bran using concentrated alkali.

eCollection 2018 Oct 31.

COVID-19 is an emerging, rapidly evolving situation.

For example, cell suspension culture of sugar beet and corn can obtain water-soluble glucose ester of ferulic acid, sucrose ferulate, etc., and the content can be as high as 20.0unol/g. [8], Asterid eudicot plants can also produce ferulic acid.

Recent studies have found that most of the ferulic acid in wheat bran can be released in a relatively short period of time by increasing the extraction temperature and adding a suitable protective agent. Due to the complex composition of the lye, especially the pigment material, at present, the separation method of ferulic acid in the lye mainly adopts the activated carbon adsorption method. [citation needed], Although there are many sources of ferulic acid in nature, its bioavailability depends on the form in which it is present: free ferulic acid has limited solubility in water, and hence poor bioavailability.

It is an intermediate in the synthesis of monolignols, i.e., the monomers of lignin, and is also used for the synthesis of lignans. Int J Toxicol. The adsorption method is a purification method which is currently studied more.

The principle is that the ferulic acid in the solution is adsorbed and enriched by adding an adsorbent material, and then the adsorbed ferulic acid is eluted by an eluent. It is an abundant phenolic phytochemical found in plant cell walls, covalently bonded as side chains to molecules such as arabinoxylans. The catalysts include piperidine and aniline. [23], 2-propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+, InChI=1/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+, Except where otherwise noted, data are given for materials in their, DTXSID70892035 DTXSID5040673, DTXSID70892035, 10.1002/(SICI)1097-0010(19990301)79:3<396::AID-JSFA262>3.0.CO;2-B, "Potential applications of ferulic acid from natural sources", "Inhibitory effect of ferulic acid and isoferulic acid on the production of macrophage inflammatory protein-2 in response to respiratory syncytial virus infection in RAW264.7 cells", "Cooking sweet corn boosts its ability to fight cancer and heart disease by freeing healthful compounds, Cornell scientists find", "Microbial transformations of ferulic acid by Saccharomyces cerevisiae and Pseudomonas fluorescens", "Purification and characterization of a ferulic acid decarboxylase from Pseudomonas fluorescens",, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles with unsourced statements from December 2019, Creative Commons Attribution-ShareAlike License, 168 to 172 °C (334 to 342 °F; 441 to 445 K), This page was last edited on 2 October 2020, at 09:51. [16], Ferulic acid is biosynthesized in plants from caffeic acid by the action of the enzyme caffeate O-methyltransferase. Substituent Effect on the Formation of Arylindanes by Dimerization of Ferulic Acid and its Related Compounds.

Ferulic acid can be obtained from plants in three ways: one is obtained from a combination of ferulic acid and some small molecules. J Agric Food Chem. 2001 Apr;92(4):404-9. doi: 10.1111/j.1349-7006.2001.tb01109.x. Get the latest public health information from CDC: The reaction method is to hydrolyze oryzanol to prepare ferulic acid. As a component of lignin, ferulic acid is a precursor in the manufacture of other aromatic compounds.

As a building block of lignocelluloses, such as pectin[2] and lignin, ferulic acid is ubiquitous in the plant kingdom. Please enable it to take advantage of the complete set of features! Get the latest research from NIH:

As polysaccharide ferulate is a natural and abundant source of ferulic acid, preparation of ferulic acid from plant cell wall materials will be a prospective pathway.

Rice bran fermented with saccharomyces boulardii generates novel metabolite profiles with bioactivity.

[6] The highest known concentration of ferulic acid glucoside has been found in flaxseed (4.1 ± 0.2 g/kg). The name is derived from the genus Ferula, referring to the giant fennel (Ferula communis). Ryan EP, Heuberger AL, Weir TL, Barnett B, Broeckling CD, Prenni JE. This site needs JavaScript to work properly. Fungi, bacteria and yeast all secrete ferulic acid esterase.

Clipboard, Search History, and several other advanced features are temporarily unavailable. [22], It is used as a matrix for proteins in MALDI mass spectrometry analyses.

Couteau was screened from adsorption media such as activated carbon, polystyrene cross-linked resin, and PVPP.

Callus (dry weight). J Agric Food Chem. The advantage is the best adsorption medium.

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